Like for example, on pre-afterbirth I found a seed that started you as Eden with the knife and a blank card, and one of the first rooms dropped an emperor card. You have the option on the second floor I think it is to either go Brimstone + Tammy's Head or take Brim + Undefined all the way down. Other than the 'secret' seeds that do silly things (like make Isaac camoflauged with the floor) yeah it's just replay value.

The Binding of Isaac: Repentance features hundreds of new features and quality-of-life improvements. BED8 G74F: Had Brimstone + 8 other items by the end of either the first or second floor (I think I played as Isaac) 76CD 7J0B: Eden - Undefined run. THE 'FINAL' UPDATE TO THE AWARD-WINNING CLASSIC There are more features, improvements and new secrets, too many secrets, than most games would include in an official sequel! It's an immense amount of new content to explore, even if you're at 1,000,000%! Play as Isaac (with d6 if you want crickets body) and go up into an room with a bomb chest or whatever they're called and blow it up. The Binding of Isaac: Repentance is so huge, so new and so feature-packed that it makes previous updates look like prequels.

unholy terrors from his wildest dreams and worst nightmares! It's a game too big to be called a sequel: Repentance takes Isaac to new heights of roguelike dungeon adventure, as the brave boy descends into the basement for his greatest challenge yet! Isaac's new quest takes him to unknown places he's never been, filled with horrible new enemies and bosses, weapon combos you've never synergized before and items he's never seen. You’ll have to accomplish some challenging in-game tasks in order to unlock them all, but once you do, you’ll be able to begin each new run with dramatically different starting items and abilities. Experience the modern classic, The Binding of Isaac, like you've never seen it before. Repentance has 34 different playable characters: 17 unique protagonists, plus an alternate tainted version of each one.

The binding of isaac seeds